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CD80 Antibody [3H5] (PE)

CAT: 0223-76-049Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-049Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) . CD28 also binds a second B7 ligand known as CD86 (B7-2) . Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The 3H5 antibody blocks the binding of CD80 to its ligands.
NCBI Gene ID
25408
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Clone
3H5
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity, Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) .
Symbol
Cd80
NCBI Official Name
Cd80 molecule
NCBI Organism
Rattus norvegicus
Background Reference 01
Damoiseaux, J. G., Yagita, H., Okumura, K., van Breda Vriesman, P. J. (1998) . Costimulatory molecules CD80 and CD86 in the rat
Background Reference 02
Maeda, K., Sato, T., Azuma, M., Yagita, H., Okumura, K. (1997) . Characterization of rat CD80 and CD86 by molecular cloning and mAb.International immunology,9 (7), 993-1000.
Background Reference 03
Bluestone, J. A. (1995) . New perspectives of CD28-B7-mediated T cell costimulation.Immunity,2 (6), 555-559.
Other Product Names
B7-1, Cd80
Tested Applications
Flow
Physical Properties
Liquid

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