CD80 Antibody [16-10A1] (FITC)

• Background:

  The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) . CD28 also binds a second B7 ligand known as CD86 (B7-2) . Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

• NCBI Gene ID:

  12519

• Swiss Prot:

  Q00609

• Host:

  Hamster

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  16-10A1

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity, Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Armenian Hamster IgG

• Specificity:

  The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) .

• Symbol:

  Cd80

• NCBI Official Name:

  CD80 antigen

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Razi-Wolf, Z., Freeman, G. J., Galvin, F., Benacerraf, B., Nadler, L., Reiser, H. (1992) . Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.Proceedings of the National Academy of Sciences,89 (9), 4210-4214.

• Background Reference 02:

  Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., Hodes, R. J. (1994) . Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.The Journal of experimental medicine,180 (2), 631-640.

• Background Reference 03:

  Harlan, D. M., Hengartner, H., Huang, M. L., Kang, Y. H., Abe, R., Moreadith, R. W., ... Freeman, G. J. (1994) . Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.Proceedings of the National Academy of Sciences,91 (8), 3137-3141.

• Other Product Names:

  B71, Ly53, TSA1, Cd28l, Ly-53, MIC17, Cd80

• Tested Applications:

  Flow

• Physical Properties:

  Liquid