AKT2 Antibody

• Background:

  Murine thymoma viral (v-akt) homolog-2; rac protein kinase β . AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.

• NCBI Gene ID:

  208

• Swiss Prot:

  P31751

• Accession Number:

  NP_001617.1

• Host:

  Chicken

• Reactivity:

  Human

• Immunogen:

  108-124

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Neuroscience, Signal Transduction

• Purification:

  Antigen affinity-purified

• Concentration:

  1 mg/mL

• Buffer:

  Phosphate-Buffered Saline. No preservatives added.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  AKT2 antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55.8 kDa (calculated)

• Applications Notes:

  AKT2 antibody can be used for the detection of AKT2 by Western blot, ELISA, may also work for IHC and ICC.

• Symbol:

  AKT2

• NCBI Official Name:

  V-akt murine thymoma viral oncogene homolog 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cheng, J. Q., Ruggeri, B., Klein, W. M., Sonoda, G., Altomare, D. A., Watson, D. K., Testa, J. R. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Nat. Acad. Sci. 93: 3636-3641, 1996.

• Other Product Names:

  Protein kinase Akt-2, PKB beta, PKBB, PRKBB, HIHGHH, PKBBETA, RAC-BETA

• Tested Applications:

  ELISA

• Protein ID:

  4502023

• Physical Properties:

  Liquid