PSG3 Antibody

• Background:

  The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]) . For additional general information about the PSG gene family, see PSG1 (MIM 176390) .

• NCBI Gene ID:

  5671

• Swiss Prot:

  Q16557

• Accession Number:

  Q16557

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PSG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human PSG3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PSG3

• NCBI Official Name:

  Pregnancy-specific beta-1-glycoprotein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Colland, F., et al. Genome Res. 14 (7) :1324-1332 (2004)

• Background Reference 02:

  Grimwood, J., et al. Nature 428 (6982) :529-535 (2004)

• Background Reference 03:

  Teglund, S., et al. Genomics 23 (3) :669-684 (1994)

• Background Reference 04:

  Olsen, A., et al. Genomics 23 (3) :659-668 (1994)

• Other Product Names:

  Pregnancy-specific beta-1-glycoprotein 3, PS-beta-G-3, PSBG-3, Pregnancy-specific glycoprotein 3, Carcinoembryonic antigen SG5, PSG3

• Tested Applications:

  WB

• Protein ID:

  108935880

• Physical Properties:

  Liquid