CLASP2 Antibody

• Background:

  CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

• NCBI Gene ID:

  23122

• Swiss Prot:

  O75122

• Accession Number:

  O75122

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CLASP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1026 amino acids from human CLASP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  141 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CLASP2

• NCBI Official Name:

  CLIP-associating protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Inkster, B., et.al., Neuroimage (2010) In press.

• Other Product Names:

  CLIP-associating protein 2, Cytoplasmic linker-associated protein 2, Protein Orbit homolog 2, hOrbit2, CLASP2, KIAA0627

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid