CYP3A4 Antibody

• Background:

  CYP3A4, is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens.

• NCBI Gene ID:

  1576

• Swiss Prot:

  P08684

• Accession Number:

  P08684

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYP3A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-255 amino acids from the Central region of human CYP3A4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CYP3A4

• NCBI Official Name:

  Cytochrome P450 3A4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sandanaraj, E., Clin. Cancer Res. 14 (21), 7116-7126 (2008)

• Background Reference 02:

  Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)

• Background Reference 03:

  Inoue, K., Jpn. J. Hum. Genet. 37 (2), 133-138 (1992)

• Other Product Names:

  Cytochrome P450 3A4, 11413-,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxygenase, Taurochenodeoxycholate 6-alpha-hydroxylase, CYP3A4, CYP3A3

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  116241312

• Physical Properties:

  Liquid