CLASP2 Antibody

CAT: 0223-62-710Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-710Size:400 µL
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Background
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
NCBI Gene ID
23122
Swiss Prot
O75122
Accession Number
O75122
Host
Rabbit
Reactivity
Human
Immunogen
This CLASP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 946-975 amino acids from the C-terminal region of human CLASP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
141 kDa
Fragment
Rabbit Ig
Symbol
CLASP2
NCBI Official Name
CLIP-associating protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Pereira, A.L., Mol. Biol. Cell 17 (10), 4526-4542 (2006)
Background Reference 02
Mimori-Kiyosue, Y., Genes Cells 11 (8), 845-857 (2006)
Background Reference 03
Lansbergen, G., Dev. Cell 11 (1), 21-32 (2006)
Other Product Names
CLIP-associating protein 2, Cytoplasmic linker-associated protein 2, Protein Orbit homolog 2, hOrbit2, CLASP2, KIAA0627
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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