AKT2 Antibody

• Background:

  AKT2 is a putative oncogenic protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.

• NCBI Gene ID:

  208

• Swiss Prot:

  P31751

• Accession Number:

  P31751

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This AKT2 antibody is generated from rabbits immunized with human AKT2 recombinant protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  AKT2

• NCBI Official Name:

  RAC-beta serine/threonine-protein kinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vojtek, A.B., et al., Mol. Cell. Biol. 23 (13) :4417-4427 (2003) . Yuan, Z.Q., et al., J. Biol. Chem. 278 (26) :23432-23440 (2003) . Jones, D.T., et al., Blood 101 (8) :3174-3180 (2003) . Brozinick, J.T. Jr., et al., Diabetes 52 (4) :935-941 (2003) . Miyakawa, M., et al., Endocr. J. 50 (1) :77-83 (2003) .

• Other Product Names:

  RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B beta, PKB beta, RAC-PK-beta, AKT2

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  1170703

• Physical Properties:

  Liquid