AKT2 Antibody

• Background:

  AKT2 is a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. AKT2 has been shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.

• NCBI Gene ID:

  208

• Swiss Prot:

  P31751

• Accession Number:

  P31751

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AKT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 416-444 amino acids from the C-terminal region of human AKT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  AKT2

• NCBI Official Name:

  RAC-beta serine/threonine-protein kinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  George, S., et al., Science 304 (5675) :1325-1328 (2004) .

• Background Reference 02:

  Xu, X., et al., Oncol. Rep. 11 (1) :25-32 (2004) .

• Background Reference 03:

  Shim, D., et al., Arch. Biochem. Biophys. 425 (2) :214-220 (2004) .

• Background Reference 04:

  Li, X., et al., Gastroenterology 126 (1) :122-135 (2004) .

• Other Product Names:

  RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B beta, PKB beta, RAC-PK-beta, AKT2

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  1170703

• Physical Properties:

  Liquid