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VDAC1 Antibody

CAT: 0223-62-367Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-367Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
NCBI Gene ID
7416
Swiss Prot
P21796
Accession Number
P21796
Host
Rabbit
Reactivity
Human
Immunogen
This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human VDAC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Symbol
VDAC1
NCBI Official Name
Voltage-dependent anion-selective channel protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Shoshan-Barmatz, V., Biochim. Biophys. Acta 1787 (5), 421-430 (2009)
Background Reference 02
Hiller, S., Science 321 (5893), 1206-1210 (2008)
Other Product Names
Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC1, VDAC
Tested Applications
WB, IHC-P, Flow
Protein ID
130683
Physical Properties
Liquid

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