VDAC1 Antibody

• Background :

  VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

• NCBI Gene ID :

  7416

• Swiss Prot :

  P21796

• Accession Number :

  P21796

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human VDAC1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  31 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  VDAC1

• NCBI Official Name :

  Voltage-dependent anion-selective channel protein 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Shoshan-Barmatz, V., Biochim. Biophys. Acta 1787 (5), 421-430 (2009)

• Background Reference 02 :

  Hiller, S., Science 321 (5893), 1206-1210 (2008)

• Other Product Names :

  Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC1, VDAC

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  130683

• Physical Properties :

  Liquid