Synphilin-1 Antibody

• Background:

  Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease

• NCBI Gene ID:

  9627

• Swiss Prot:

  Q9Y6H5

• Accession Number:

  Q9Y6H5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Synphilin-1 (SNCAIP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-622 amino acids from the C-terminal region of human Synphilin-1 (SNCAIP) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  100 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SNCAIP

• NCBI Official Name:

  Synphilin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kruger, R. Cell Tissue Res. 318 (1), 195-199 (2004)

• Background Reference 02:

  Lee, G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004)

• Background Reference 03:

  Tanaka, M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004)

• Background Reference 04:

  Nagano, Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003)

• Other Product Names:

  Synphilin-1, Sph1, Alpha-synuclein-interacting protein, SNCAIP

• Tested Applications:

  WB

• Protein ID:

  205831000

• Physical Properties:

  Liquid