NOTCH3 Antibody

• Background:

  NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

• NCBI Gene ID:

  4854

• Swiss Prot:

  Q9UM47

• Accession Number:

  Q9UM47

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This NOTCH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Human

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  244 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NOTCH3

• NCBI Official Name:

  Neurogenic locus notch homolog protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Suwanwela, N., et al., Med Assoc Thai 86 (2) :178-182 (2003) . Ahearn, E.P., et al., Am. J. Med. Genet. 114 (6) :652-658 (2002) . Bellavia, D., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (6) :3788-3793 (2002) . Ito, D., et al., J. Neurol. Neurosurg. Psychiatr. 72 (3) :382-384 (2002) . Joutel, A., et al., Lancet 350 (9090) :1511-1515 (1997) .

• Other Product Names:

  Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  322510053

• Physical Properties:

  Liquid