Products for Research Use Only
RegisterLogin

ARHGEF3 Antibody

CAT: 0223-62-060Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-62-060Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
50650
Swiss Prot
Q9NR81
Accession Number
Q9NR81
Host
Rabbit
Reactivity
Human
Immunogen
This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
ARHGEF3
NCBI Official Name
Rho guanine nucleotide exchange factor 3
NCBI Organism
Homo sapiens
Background Reference 01
Arthur, W.T., et al. J. Biol. Chem. 277 (45) :42964-42972 (2002)
Background Reference 02
Harrington, A.W., et al. J. Neurosci. 22 (1) :156-166 (2002)
Background Reference 03
Simpson, J.C., et al. EMBO Rep. 1 (3) :287-292 (2000)
Background Reference 04
Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273 (1) :364-369 (2000)
Other Product Names
Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3
Tested Applications
WB, IHC-P
Protein ID
52782760
Physical Properties
Liquid

Related Products

CatalogName
61-443Arhgef9 Antibody
58-055ARHGEF1 Antibody
61-358ARHGEF7 Antibody
58-689ARHGEF5 Antibody
14-499ARHGEF2 Antibody
13-905ARHGEF7 Antibody
23-314ARHGEF9 Antibody
45-281ARHGEF4 Antibody
19-304ARHGEF5 Antibody
16-836ARHGEF5 Antibody

Alternative Products

CatalogName
MBS859100-01ARHGEF3 Antibody

Popular Products