SULT2A Antibody

• Background:

  One of the major roles of the sulfotransferases (ST) in the metabolism of drugs and endogenous compounds is the conversion of these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. Sulfation may also play a regulatory role for many endogenous compounds, such as steroids and neurotransmitters, by altering the biologic properties of these compounds. Otterness et al. (1992), Kong et al. (1992), and Comer et al. (1993) reported the cloning of cDNAs encoding liver dehydroepiandrosterone (DHEA) sulfotransferase. The predicted protein has 285 amino acids. Although Northern blot analysis of human liver RNA detected transcripts of 3 different sizes, Southern blot analysis of human DNA suggested that only 1 gene is present in the genome. This gene has an important role in the sulfation of both bile acids and steroids in the liver and adrenals. The human adrenal form of this enzyme is physically, immunologically, and kinetically similar, perhaps identical, to the liver form. Dehydroepiandrosterone sulfate is quantitatively one of the major steroids secreted from the adrenal cortex.

• NCBI Gene ID:

  6822

• Swiss Prot:

  Q06520

• Accession Number:

  Q06520

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SULT2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-285 amino acids from the C-terminal region of human SULT2A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SULT2A1

• NCBI Official Name:

  Bile salt sulfotransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Otterness, D. M., et al. Molec. Pharm. 41: 865-872 (1992) .

• Background Reference 02:

  Kong, A.-N. T., et al. Biochem. Biophys. Res. Commun. 187: 448-454 (1992) .

• Background Reference 03:

  Comer, K. A., et al. Biochem. J. 289: 233-240 (1993) .

• Other Product Names:

  Bile salt sulfotransferase, Dehydroepiandrosterone sulfotransferase, DHEA-ST, Hydroxysteroid Sulfotransferase, HST, ST2, ST2A3, Sulfotransferase 2A1, ST2A1, SULT2A1, HST, STD

• Tested Applications:

  WB

• Protein ID:

  1711591

• Physical Properties:

  Liquid