Vinculin

• Background :

  Actin filament (F-actin) -binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity) .

• NCBI Gene ID :

  22330

• Swiss Prot :

  Q64727

• Accession Number :

  Q64727

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 903-937 amino acids from mouse.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  117 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:2000

• Symbol :

  Vcl

• NCBI Official Name :

  Vinculin

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Coll J.-L., et al.Proc. Natl. Acad. Sci. U.S.A. 92:9161-9165 (1995) .

• Background Reference 02 :

  Alatortsev V.E., et al.FEBS Lett. 413:197-201 (1997) .

• Background Reference 03 :

  Carninci P., et al.Science 309:1559-1563 (2005) .

• Background Reference 04 :

  Lubec G., et al.Submitted (JAN-2009) to UniProtKB.

• Other Product Names :

  Vinculin, Metavinculin, Vcl

• Tested Applications :

  WB

• Physical Properties :

  Liquid