Vinculin

• Background:

  Actin filament (F-actin) -binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity) .

• NCBI Gene ID:

  22330

• Swiss Prot:

  Q64727

• Accession Number:

  Q64727

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 634-668 amino acids from mouse.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  117 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Vcl

• NCBI Official Name:

  Vinculin

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Coll J.-L., et al.Proc. Natl. Acad. Sci. U.S.A. 92:9161-9165 (1995) .

• Background Reference 02:

  Alatortsev V.E., et al.FEBS Lett. 413:197-201 (1997) .

• Background Reference 03:

  Carninci P., et al.Science 309:1559-1563 (2005) .

• Background Reference 04:

  Lubec G., et al.Submitted (JAN-2009) to UniProtKB.

• Other Product Names:

  Vinculin, Metavinculin, Vcl

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid