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CHK1 Antibody

CAT: 0223-61-138Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-138Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.
NCBI Gene ID
1111
Swiss Prot
O14757
Accession Number
O14757
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CHK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from human CHK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CHEK1
NCBI Official Name
Serine/threonine-protein kinase Chk1
NCBI Organism
Homo sapiens
Background Reference 01
Kaneko M, FEBS Lett. 2002. 532: 147-152.
Background Reference 02
Amano T, et al. Genes Dev. 2003. 17: 2436-2449.
Other Product Names
Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, CHEK1, CHK1
Tested Applications
WB
Physical Properties
Liquid

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