UBE2B Antibody

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2B is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.

• NCBI Gene ID:

  7320

• Swiss Prot:

  P63146

• Accession Number:

  P63146

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UBE2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human UBE2B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Bovine, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  17 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UBE2B

• NCBI Official Name:

  Ubiquitin-conjugating enzyme E2 B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Koken, M.H., et al., Genomics 12 (3) :447-453 (1992) .

• Background Reference 02:

  Koken, M.H., et al., Proc. Natl. Acad. Sci. U.S.A. 88 (20) :8865-8869 (1991) .

• Background Reference 03:

  Schneider, R., et al., EMBO J. 9 (5) :1431-1435 (1990) .

• Other Product Names:

  Ubiquitin-conjugating enzyme E2 B, RAD6 homolog B, HR6B, hHR6B, Ubiquitin carrier protein B, Ubiquitin-conjugating enzyme E2-17 kDa, Ubiquitin-protein ligase B, UBE2B, RAD6B

• Tested Applications:

  WB, IHC-P

• Protein ID:

  52783814

• Physical Properties:

  Liquid