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NeuroD1 Antibody

CAT: 0223-60-932Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-932Size:400 µL
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Background
NeuroD1 acts as a differentiation factor during neurogenesis. They are expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation. NeuroD1 is a basic helix-loop-helix (bHLH) protein contain 1 bHLH domain. NeuroD1 is a transcriptional activator, for efficient DNA binding it requires dimerization with another bHLH protein. It was reported that NeuroD1 involves heterodimerization with the ubiquitous bHLH protein E47, and regulates insulin gene expression by binding to a critical E-box motif on the insulin promoter. Defects in NEUROD1 causes maturity onset diabetes of the young type VI. MODY6 is a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
NCBI Gene ID
4760
Swiss Prot
Q13562
Accession Number
Q13562
Host
Rabbit
Reactivity
Human
Immunogen
This NeuroD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human NeuroD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Symbol
NEUROD1
NCBI Official Name
Neurogenic differentiation factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Breslin, M.B., et al., J. Biol. Chem. 278 (40) :38991-38997 (2003) .
Background Reference 02
Malecki, M.T., et al., Acta Diabetol 40 (2) :109-111 (2003) .
Background Reference 03
Cinek, O., et al., Diabetes Res. Clin. Pract. 60 (1) :49-56 (2003) .
Background Reference 04
Ye, L., et al., Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19 (6) :484-487 (2002) .
Other Product Names
Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3, NEUROD1, BHLHA3, NEUROD
Tested Applications
WB, IHC-P, IF
Protein ID
311033428
Physical Properties
Liquid

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