GFAP Antibody

• Background:

  GFAP is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.

• NCBI Gene ID:

  2670

• Swiss Prot:

  P14136

• Accession Number:

  P14136

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This GFAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 amino acids from the C-terminal region of human GFAP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GFAP

• NCBI Official Name:

  Glial fibrillary acidic protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Quintanar, J.L., et al., Parasitol. Res. 90 (4) :261-263 (2003) .

• Background Reference 02:

  Shiroma, N., et al., Brain Dev. 25 (2) :116-121 (2003) .

• Background Reference 03:

  Nielsen, A.L., et al., J. Biol. Chem. 277 (33) :29983-29991 (2002) .

• Background Reference 04:

  Namekawa, M., et al., Ann. Neurol. 52 (6) :779-785 (2002) .

• Other Product Names:

  Glial fibrillary acidic protein, GFAP, GFAP

• Tested Applications:

  WB

• Protein ID:

  121135

• Physical Properties:

  Liquid