TIAM1 Antibody

• Background:

  Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

• NCBI Gene ID:

  7074

• Swiss Prot:

  Q13009

• Accession Number:

  Q13009

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TIAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1478-1506 amino acids from the C-terminal region of human TIAM1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  178 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TIAM1

• NCBI Official Name:

  T-lymphoma invasion and metastasis-inducing protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yang, W., et al. Jpn. J. Clin. Oncol. 40 (11) :1053-1059 (2010)

• Background Reference 02:

  Moriarty, C.H., et al. J. Biol. Chem. 285 (27) :20541-20546 (2010)

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Rajagopal, S., et al. J. Biol. Chem. 285 (23) :18060-18071 (2010)

• Other Product Names:

  T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1

• Tested Applications:

  WB

• Protein ID:

  152031709

• Physical Properties:

  Liquid