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RELA Antibody

CAT: 0223-60-732Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-732Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1) /p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine) .
NCBI Gene ID
5970
Swiss Prot
Q04206
Accession Number
Q04206
Host
Rabbit
Reactivity
Human
Immunogen
This RELA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-195 amino acids from the Central region of human RELA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Obesity, Immunology, Cell Cycle, Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
RELA
NCBI Official Name
Transcription factor p65
NCBI Organism
Homo sapiens
Background Reference 01
Pan, W.W., et al. J. Biol. Chem. 285 (45) :34348-34354 (2010)
Background Reference 02
Tago, K., et al. J. Biol. Chem. 285 (40) :30622-30633 (2010)
Background Reference 03
Park, J.S., et al. Oncol. Rep. 24 (3) :709-714 (2010)
Background Reference 04
Yu, Z.H., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26 (7) :650-652 (2010)
Other Product Names
Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Tested Applications
WB, IF
Protein ID
62906901
Physical Properties
Liquid

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