MTA1 Antibody

• Background:

  This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. [provided by RefSeq].

• NCBI Gene ID:

  9112

• Swiss Prot:

  Q13330

• Accession Number:

  Q13330

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MTA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-687 amino acids from the C-terminal region of human MTA1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  81 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MTA1

• NCBI Official Name:

  Metastasis-associated protein MTA1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhu, X., et al.Thorac Oncol 5 (8) :1159-1166 (2010)

• Background Reference 02:

  Van Rechem, C., et al. Mol. Cell. Biol. 30 (16) :4045-4059 (2010)

• Background Reference 03:

  Yang, Y.M., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26 (7) :682-684 (2010)

• Background Reference 04:

  Li, D.Q., et al. J. Biol. Chem. 285 (26) :19802-19812 (2010)

• Other Product Names:

  Metastasis-associated protein MTA1, MTA1

• Tested Applications:

  WB

• Protein ID:

  259016275

• Physical Properties:

  Liquid