GTPBP3 Antibody

• Background:

  This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described.

• NCBI Gene ID:

  84705

• Swiss Prot:

  Q969Y2

• Accession Number:

  Q969Y2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GTPBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the Central region of human GTPBP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GTPBP3

• NCBI Official Name:

  TRNA modification GTPase GTPBP3, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Reiling, E., et al. Eur. J. Hum. Genet. 17 (8) :1056-1062 (2009)

• Background Reference 02:

  Villarroya, M., et al. Mol. Cell. Biol. 28 (24) :7514-7531 (2008)

• Background Reference 03:

  Bykhovskaya, Y., et al. Mol. Genet. Metab. 83 (3) :199-206 (2004)

• Background Reference 04:

  Li, X., et al. Biochem. Biophys. Res. Commun. 312 (3) :747-754 (2003)

• Other Product Names:

  TRNA modification GTPase GTPBP3, mitochondrial, GTP-binding protein 3, Mitochondrial GTP-binding protein 1, GTPBP3, MTGP1

• Tested Applications:

  WB

• Protein ID:

  313104112

• Physical Properties:

  Liquid