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FANCL Antibody

CAT: 0223-60-582Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-582Size:400 µL
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Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
NCBI Gene ID
55120
Swiss Prot
Q9NW38
Accession Number
Q9NW38
Host
Rabbit
Reactivity
Human
Immunogen
This FANCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the C-terminal region of human FANCL.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FANCL
NCBI Official Name
E3 ubiquitin-protein ligase FANCL
NCBI Organism
Homo sapiens
Background Reference 01
Zhang, J., et al. J. Clin. Invest. 120 (5) :1524-1534 (2010)
Background Reference 02
Garcia, M.J., et al. Carcinogenesis 30 (11) :1898-1902 (2009)
Background Reference 03
McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18 (9) :2549-2552 (2009)
Background Reference 04
Longerich, S., et al. J. Biol. Chem. 284 (35) :23182-23186 (2009)
Other Product Names
E3 ubiquitin-protein ligase FANCL, 632-, Fanconi anemia group L protein, Fanconi anemia-associated polypeptide of 43 kDa, FAAP43, FANCL, PHF9
Tested Applications
WB
Protein ID
116241360
Physical Properties
Liquid

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