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RNF128 Antibody

CAT: 0223-60-487Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-487Size:400 µL
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Background
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
NCBI Gene ID
79589
Swiss Prot
Q8TEB7
Accession Number
Q8TEB7
Host
Rabbit
Reactivity
Human
Immunogen
This RNF128 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human RNF128.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RNF128
NCBI Official Name
E3 ubiquitin-protein ligase RNF128
NCBI Organism
Homo sapiens
Background Reference 01
Su, L.L., et al. J. Immunol. 183 (1) :438-444 (2009)
Background Reference 02
Lin, J.T., et al. J. Immunol. 182 (10) :5919-5928 (2009)
Background Reference 03
Lineberry, N., et al. J. Biol. Chem. 283 (42) :28497-28505 (2008)
Background Reference 04
Egawa, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (1), G163-G169 (2008) :
Other Product Names
E3 ubiquitin-protein ligase RNF128, 632-, Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RNF128
Tested Applications
WB
Protein ID
74751443
Physical Properties
Liquid

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