RNF128 Antibody

• Background :

  The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

• NCBI Gene ID :

  79589

• Swiss Prot :

  Q8TEB7

• Accession Number :

  Q8TEB7

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This RNF128 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human RNF128.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  47 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  RNF128

• NCBI Official Name :

  E3 ubiquitin-protein ligase RNF128

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Su, L.L., et al. J. Immunol. 183 (1) :438-444 (2009)

• Background Reference 02 :

  Lin, J.T., et al. J. Immunol. 182 (10) :5919-5928 (2009)

• Background Reference 03 :

  Lineberry, N., et al. J. Biol. Chem. 283 (42) :28497-28505 (2008)

• Background Reference 04 :

  Egawa, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (1), G163-G169 (2008) :

• Other Product Names :

  E3 ubiquitin-protein ligase RNF128, 632-, Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RNF128

• Tested Applications :

  WB

• Protein ID :

  74751443

• Physical Properties :

  Liquid