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GPR109B Antibody

CAT: 0223-60-420Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-420Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
NCBI Gene ID
8843
Swiss Prot
P49019
Accession Number
P49019
Host
Rabbit
Reactivity
Human
Immunogen
This GPR109B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the N-terminal region of human GPR109B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HCAR3
NCBI Official Name
Hydroxycarboxylic acid receptor 3
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 02
Mandrika, I., et al. Biochem. Biophys. Res. Commun. 395 (2) :281-287 (2010)
Background Reference 03
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 04
Jeninga, E.H., et al. J. Biol. Chem. 284 (39) :26385-26393 (2009)
Other Product Names
Hydroxycarboxylic acid receptor 3, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2, Nicotinic acid receptor 2, HCAR3, GPR109B, HCA3, HM74B, NIACR2
Tested Applications
WB
Protein ID
519668680
Physical Properties
Liquid

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