DUSP13 Antibody

• Background:

  Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.

• NCBI Gene ID:

  51207

• Swiss Prot:

  Q6B8I1

• Accession Number:

  Q6B8I1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DUSP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-173 amino acids from the C-terminal region of human DUSP13.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  21 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DUSP13

• NCBI Official Name:

  Dual specificity protein phosphatase 13 isoform A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, S.J., et al. Proteins 66 (1) :239-245 (2007)

• Background Reference 02:

  Grupe, A., et al. Am. J. Hum. Genet. 78 (1) :78-88 (2006)

• Background Reference 03:

  Barrios-Rodiles, M., et al. Science 307 (5715) :1621-1625 (2005)

• Background Reference 04:

  Chen, H.H., et al. J. Biol. Chem. 279 (40) :41404-41413 (2004)

• Other Product Names:

  Dual specificity protein phosphatase 13 isoform A, DUSP13A, Branching-enzyme interacting DSP, Muscle-restricted DSP, MDSP, DUSP13, BEDP, DUSP13A, MDSP

• Tested Applications:

  WB

• Protein ID:

  74748394

• Physical Properties:

  Liquid