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DUSP13 Antibody

CAT: 0223-60-124Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-124Size:400 µL
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Background
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.
NCBI Gene ID
51207
Swiss Prot
Q6B8I1
Accession Number
Q6B8I1
Host
Rabbit
Reactivity
Human
Immunogen
This DUSP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-173 amino acids from the C-terminal region of human DUSP13.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DUSP13
NCBI Official Name
Dual specificity protein phosphatase 13 isoform A
NCBI Organism
Homo sapiens
Background Reference 01
Kim, S.J., et al. Proteins 66 (1) :239-245 (2007)
Background Reference 02
Grupe, A., et al. Am. J. Hum. Genet. 78 (1) :78-88 (2006)
Background Reference 03
Barrios-Rodiles, M., et al. Science 307 (5715) :1621-1625 (2005)
Background Reference 04
Chen, H.H., et al. J. Biol. Chem. 279 (40) :41404-41413 (2004)
Other Product Names
Dual specificity protein phosphatase 13 isoform A, DUSP13A, Branching-enzyme interacting DSP, Muscle-restricted DSP, MDSP, DUSP13, BEDP, DUSP13A, MDSP
Tested Applications
WB
Protein ID
74748394
Physical Properties
Liquid

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