TBC1D2 Antibody

• Background :

  TBC1D2 acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivativation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.

• NCBI Gene ID :

  55357

• Swiss Prot :

  Q9BYX2

• Accession Number :

  Q9BYX2

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This TBC1D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-465 amino acids from the Central region of human TBC1D2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  105 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  TBC1D2

• NCBI Official Name :

  TBC1 domain family member 2A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Letra, A., et al. Am. J. Med. Genet.152A (7), 1701-1710 (2010) :

• Background Reference 02 :

  Ishibashi, K., et al. Genes Cells 14 (1) :41-52 (2009)

• Background Reference 03 :

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 04 :

  Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (33) :12130-12135 (2004)

• Other Product Names :

  TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1, TBC1D2, PARIS1, PP8997, TBC1D2A

• Tested Applications :

  WB

• Protein ID :

  300669706

• Physical Properties :

  Liquid