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RNF144B Antibody

CAT: 0223-59-992Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-992Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
NCBI Gene ID
255488
Swiss Prot
Q7Z419
Accession Number
Q7Z419
Host
Rabbit
Reactivity
Human
Immunogen
This RNF144B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the Central region of human RNF144B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RNF144B
NCBI Official Name
E3 ubiquitin-protein ligase RNF144B
NCBI Organism
Homo sapiens
Background Reference 01
Sayan, B.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (29) :12877-12882 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Benard, G., et al. EMBO J. 29 (8) :1458-1471 (2010)
Background Reference 04
Markson, G., et al. Genome Res. 19 (10) :1905-1911 (2009)
Other Product Names
E3 ubiquitin-protein ligase RNF144B, 632-, IBR domain-containing protein 2, RING finger protein 144B, p53-inducible RING finger protein, RNF144B, IBRDC2, P53RFP
Tested Applications
WB
Protein ID
57012811
Physical Properties
Liquid

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