GCNT2 Antibody

• Background:

  This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

• NCBI Gene ID:

  2651

• Swiss Prot:

  Q8N0V5

• Accession Number:

  Q8N0V5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-240 amino acids from the Central region of human GCNT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GCNT2

• NCBI Official Name:

  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Twu, Y.C., et al. Blood 110 (13) :4526-4534 (2007)

• Background Reference 02:

  Wang, L., et al. Biochem. Biophys. Res. Commun. 331 (4) :958-963 (2005)

• Background Reference 03:

  Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45 (6) :1940-1945 (2004)

• Background Reference 04:

  Inaba, N., et al. Blood 101 (7) :2870-2876 (2003)

• Other Product Names:

  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A, N-acetylglucosaminyltransferase, I-branching enzyme, IGNT, GCNT2, GCNT5, II, NACGT1

• Tested Applications:

  WB

• Protein ID:

  298351849

• Physical Properties:

  Liquid