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PCDHGB2 Antibody

CAT: 0223-59-844Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-844Size:400 µL
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Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
NCBI Gene ID
56103
Swiss Prot
Q9Y5G2
Accession Number
Q9Y5G2
Host
Rabbit
Reactivity
Human
Immunogen
This PCDHGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the N-terminal region of human PCDHGB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PCDHGB2
NCBI Official Name
Protocadherin gamma-B2
NCBI Organism
Homo sapiens
Background Reference 01
Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)
Background Reference 02
Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)
Background Reference 03
Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000)
Background Reference 04
Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97 (7) :3124-3129 (2000)
Other Product Names
Protocadherin gamma-B2, PCDH-gamma-B2, PCDHGB2
Tested Applications
WB
Protein ID
37999832
Physical Properties
Liquid

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