ITGB2 Antibody

• Background:

  The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1) . Two transcript variants encoding the same protein have been identified for this gene.

• NCBI Gene ID:

  3689

• Swiss Prot:

  P05107

• Accession Number:

  P05107

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ITGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from the N-terminal region of human ITGB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  85 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ITGB2

• NCBI Official Name:

  Integrin beta-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gjelstrup, L.C., et al. J. Immunol. 185 (7) :4154-4168 (2010)

• Background Reference 02:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (33) :14727-14732 (2010)

• Other Product Names:

  Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7

• Tested Applications:

  WB

• Protein ID:

  124056465

• Physical Properties:

  Liquid