ARHGEF18 Antibody

• Background:

  Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs) . The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  23370

• Swiss Prot:

  Q6ZSZ5

• Accession Number:

  Q6ZSZ5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARHGEF18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the N-terminal region of human ARHGEF18.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  131 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ARHGEF18

• NCBI Official Name:

  Rho guanine nucleotide exchange factor 18

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ichikawa, S., et al. J. Bone Miner. Res. 25 (8) :1821-1829 (2010)

• Background Reference 02:

  Niu, J., et al. Circ. Res. 93 (9) :848-856 (2003)

• Background Reference 03:

  Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :

• Background Reference 04:

  Salehi, A.H., et al. J. Biol. Chem. 277 (50) :48043-48050 (2002)

• Other Product Names:

  Rho guanine nucleotide exchange factor 18, 114 kDa Rho-specific guanine nucleotide exchange factor, p114-Rho-GEF, p114RhoGEF, Septin-associated RhoGEF, SA-RhoGEF, ARHGEF18, KIAA0521

• Tested Applications:

  WB

• Protein ID:

  296439444

• Physical Properties:

  Liquid