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PCDHA10 Antibody

CAT: 0223-59-230Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-230Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
NCBI Gene ID
56139
Swiss Prot
Q9Y5I2
Accession Number
Q9Y5I2
Host
Rabbit
Reactivity
Human
Immunogen
This PCDHA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-798 amino acids from the C-terminal region of human PCDHA10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
103 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PCDHA10
NCBI Official Name
Protocadherin alpha-10
NCBI Organism
Homo sapiens
Background Reference 01
Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)
Background Reference 02
Schmutz, J., et al. Nature 431 (7006) :268-274 (2004)
Background Reference 03
Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)
Background Reference 04
Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)
Other Product Names
Protocadherin alpha-10, PCDH-alpha-10, PCDHA10, CNRS8
Tested Applications
WB
Protein ID
13878433
Physical Properties
Liquid

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