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KCNN1 Antibody

CAT: 0223-59-038Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-038Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
NCBI Gene ID
3780
Swiss Prot
Q92952
Accession Number
Q92952
Host
Rabbit
Reactivity
Human
Immunogen
This KCNN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human KCNN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KCNN1
NCBI Official Name
Small conductance calcium-activated potassium channel protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)
Background Reference 02
Wei, A.D., et al. Pharmacol. Rev. 57 (4) :463-472 (2005)
Background Reference 03
Arnold, S.J., et al. Neuroreport 14 (2) :191-195 (2003)
Background Reference 04
Boettger, M.K., et al. Brain 125 (PT 2), 252-263 (2002) :
Other Product Names
Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa21, KCNN1, SK
Tested Applications
WB
Protein ID
124056468
Physical Properties
Liquid

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