MRPL1 Antibody

• Background:

  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.

• NCBI Gene ID:

  65008

• Swiss Prot:

  Q9BYD6

• Accession Number:

  Q9BYD6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MRPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-97 amino acids from the N-terminal region of human MRPL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MRPL1

• NCBI Official Name:

  39S ribosomal protein L1, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Background Reference 03:

  Zhang, Z., et al. Genomics 81 (5) :468-480 (2003)

• Background Reference 04:

  Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :

• Other Product Names:

  39S ribosomal protein L1, mitochondrial, L1mt, MRP-L1, MRPL1

• Tested Applications:

  WB

• Protein ID:

  239938694

• Physical Properties:

  Liquid