DUSP12 Antibody

• Background:

  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

• NCBI Gene ID:

  11266

• Swiss Prot:

  Q9UNI6

• Accession Number:

  Q9UNI6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DUSP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human DUSP12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  38 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DUSP12

• NCBI Official Name:

  Dual specificity protein phosphatase 12

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Biernacki, M.A., et al. Cancer Res. 70 (3) :906-915 (2010)

• Background Reference 02:

  Bonham, C.A., et al. J. Biol. Chem. 284 (34) :22853-22864 (2009)

• Background Reference 03:

  Sharda, P.R., et al. Biochem. J. 418 (2) :391-401 (2009)

• Background Reference 04:

  Gao, F., et al. Zhonghua Yi Xue Za Zhi 88 (32) :2250-2253 (2008)

• Other Product Names:

  Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12

• Tested Applications:

  WB

• Protein ID:

  9973073

• Physical Properties:

  Liquid