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DUSP12 Antibody

CAT: 0223-58-792Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-792Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
NCBI Gene ID
11266
Swiss Prot
Q9UNI6
Accession Number
Q9UNI6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DUSP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human DUSP12.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DUSP12
NCBI Official Name
Dual specificity protein phosphatase 12
NCBI Organism
Homo sapiens
Background Reference 01
Biernacki, M.A., et al. Cancer Res. 70 (3) :906-915 (2010)
Background Reference 02
Bonham, C.A., et al. J. Biol. Chem. 284 (34) :22853-22864 (2009)
Background Reference 03
Sharda, P.R., et al. Biochem. J. 418 (2) :391-401 (2009)
Background Reference 04
Gao, F., et al. Zhonghua Yi Xue Za Zhi 88 (32) :2250-2253 (2008)
Other Product Names
Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Tested Applications
WB
Protein ID
9973073
Physical Properties
Liquid

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