SEPT2 Antibody

• Background:

  Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

• NCBI Gene ID:

  4735

• Swiss Prot:

  Q15019

• Accession Number:

  Q15019

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SEPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human SEPT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SEPT2

• NCBI Official Name:

  Septin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martins-de-Souza, D., et al.Psychiatr Res (2010) In press :

• Background Reference 02:

  Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

• Background Reference 03:

  Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)

• Background Reference 04:

  Shen, M., et al. Environ. Mol. Mutagen. 50 (4) :285-290 (2009)

• Other Product Names:

  Septin-2, Neural precursor cell expressed developmentally down-regulated protein 5, NEDD-5, SEPT2, DIFF6, KIAA0158, NEDD5

• Tested Applications:

  WB

• Protein ID:

  2500769

• Physical Properties:

  Liquid