SEPT2 Antibody

CAT: 0223-58-704Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-704Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
NCBI Gene ID
4735
Swiss Prot
Q15019
Accession Number
Q15019
Host
Rabbit
Reactivity
Human
Immunogen
This SEPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human SEPT2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SEPT2
NCBI Official Name
Septin-2
NCBI Organism
Homo sapiens
Background Reference 01
Martins-de-Souza, D., et al.Psychiatr Res (2010) In press :
Background Reference 02
Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)
Background Reference 03
Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)
Background Reference 04
Shen, M., et al. Environ. Mol. Mutagen. 50 (4) :285-290 (2009)
Other Product Names
Septin-2, Neural precursor cell expressed developmentally down-regulated protein 5, NEDD-5, SEPT2, DIFF6, KIAA0158, NEDD5
Tested Applications
WB
Protein ID
2500769
Physical Properties
Liquid

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