KRT3 Antibody

• Background:

  The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

• NCBI Gene ID:

  3850

• Swiss Prot:

  P12035

• Accession Number:

  P12035

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-441 amino acids from the Central region of human KRT3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KRT3

• NCBI Official Name:

  Keratin, type II cytoskeletal 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Szaflik, J.P., et al. Mol. Vis. 14, 1713-1718 (2008) :

• Background Reference 02:

  Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

• Background Reference 03:

  Chen, Y.T., et al. Cornea 24 (8) :928-932 (2005)

• Background Reference 04:

  Rogers, M.A., et al. J. Invest. Dermatol. 124 (3) :536-544 (2005)

• Other Product Names:

  Keratin, type II cytoskeletal 3, 65 kDa cytokeratin, Cytokeratin-3, CK-3, Keratin-3, K3, Type-II keratin Kb3, KRT3

• Tested Applications:

  WB

• Protein ID:

  313104225

• Physical Properties:

  Liquid