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SH3BP2 Antibody

CAT: 0223-58-642Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-642Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
6452
Swiss Prot
P78314
Accession Number
P78314
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SH3BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human SH3BP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SH3BP2
NCBI Official Name
SH3 domain-binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Lietman, S.A., et al. J. Orthop. Res. 28 (11) :1425-1430 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 04
Amaral, F.R., et al. J. Oral Pathol. Med. 39 (3) :269-274 (2010)
Other Product Names
SH3 domain-binding protein 2, 3BP-2, SH3BP2, 3BP2
Tested Applications
WB
Protein ID
3023207
Physical Properties
Liquid

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