Metabotropic Glutamate Receptor 6 Antibody

• Background:

  L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

• NCBI Gene ID:

  2916

• Swiss Prot:

  O15303

• Accession Number:

  O15303

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Metabotropic Glutamate Receptor 6 (GPRC1F) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 832-861 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 6 (GPRC1F) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  95 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GRM6

• NCBI Official Name:

  Metabotropic glutamate receptor 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hashimoto, T., et al., Eur. J. Neurosci. 9 (6) :1226-1235 (1997) .

• Other Product Names:

  Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid