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PNPLA6 Antibody

CAT: 0223-58-373Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-373Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PNPLA6 is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
10908
Swiss Prot
Q8IY17
Accession Number
Q8IY17
Host
Rabbit
Reactivity
Human
Immunogen
This PNPLA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1029 amino acids from the C-terminal region of human PNPLA6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
150 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PNPLA6
NCBI Official Name
Neuropathy target esterase
NCBI Organism
Homo sapiens
Background Reference 01
Hein, N.D., et al. Toxicol. Lett. 199 (1) :1-5 (2010)
Background Reference 02
Chen, J.X., et al. Pharmacol. Res. 62 (3) :259-264 (2010)
Background Reference 03
Greiner, A.J., et al. Biochim. Biophys. Acta 1798 (8) :1533-1539 (2010)
Background Reference 04
Hein, N.D., et al. Toxicol. Lett. 196 (2) :67-73 (2010)
Other Product Names
Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE
Tested Applications
WB
Protein ID
150403921
Physical Properties
Liquid

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