RBM5 Antibody

• Background :

  Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

• NCBI Gene ID :

  10181

• Swiss Prot :

  P52756

• Accession Number :

  P52756

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This RBM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human RBM5.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  92 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  RBM5

• NCBI Official Name :

  RNA-binding protein 5

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Sugliani, M., et al. Plant Cell 22 (6) :1936-1946 (2010)

• Background Reference 02 :

  Rintala-Maki, N.D., et al. Gene 445 (1-2), 7-16 (2009) :

• Background Reference 03 :

  Kotlajich, M.V., et al. Mol. Cell 32 (2) :162-164 (2008)

• Background Reference 04 :

  Fushimi, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (41) :15708-15713 (2008)

• Other Product Names :

  RNA-binding protein 5, Protein G15, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, Renal carcinoma antigen NY-REN-9, RBM5

• Tested Applications :

  WB

• Protein ID :

  13124794

• Physical Properties :

  Liquid