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RBM5 Antibody

CAT: 0223-58-082Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-082Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
NCBI Gene ID
10181
Swiss Prot
P52756
Accession Number
P52756
Host
Rabbit
Reactivity
Human
Immunogen
This RBM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human RBM5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
92 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RBM5
NCBI Official Name
RNA-binding protein 5
NCBI Organism
Homo sapiens
Background Reference 01
Sugliani, M., et al. Plant Cell 22 (6) :1936-1946 (2010)
Background Reference 02
Rintala-Maki, N.D., et al. Gene 445 (1-2), 7-16 (2009) :
Background Reference 03
Kotlajich, M.V., et al. Mol. Cell 32 (2) :162-164 (2008)
Background Reference 04
Fushimi, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (41) :15708-15713 (2008)
Other Product Names
RNA-binding protein 5, Protein G15, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, Renal carcinoma antigen NY-REN-9, RBM5
Tested Applications
WB
Protein ID
13124794
Physical Properties
Liquid

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