MORF4L2 Antibody

• Background:

  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

• NCBI Gene ID:

  9643

• Swiss Prot:

  Q15014

• Accession Number:

  Q15014

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MORF4L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-288 amino acids from the C-terminal region of human MORF4L2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  32 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MORF4L2

• NCBI Official Name:

  Mortality factor 4-like protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Pezo, R.C., et al. Cancer Res. 68 (13) :4977-4982 (2008)

• Background Reference 02:

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Background Reference 03:

  Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)

• Background Reference 04:

  Cai, Y., et al. J. Biol. Chem. 280 (14) :13665-13670 (2005)

• Other Product Names:

  Mortality factor 4-like protein 2, MORF-related gene X protein, Protein MSL3-2, Transcription factor-like protein MRGX, MORF4L2, KIAA0026, MRGX

• Tested Applications:

  WB

• Protein ID:

  3123049

• Physical Properties:

  Liquid