SIGLEC8 Antibody

CAT: 0223-57-823Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-823Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sialic acid-binding immunoglobulin (Ig) -like lectins, or SIGLECs (e.g., CD33 (MIM 159590) ), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]) .
NCBI Gene ID
27181
Swiss Prot
Q9NYZ4
Accession Number
Q9NYZ4
Host
Rabbit
Reactivity
Human
Immunogen
This SIGLEC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the N-terminal region of human SIGLEC8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
SIGLEC8
NCBI Official Name
Sialic acid-binding Ig-like lectin 8
NCBI Organism
Homo sapiens
Background Reference 01
Gao, P.S., et al. Eur. J. Hum. Genet. 18 (6) :713-719 (2010)
Background Reference 02
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 03
Hudson, S.A., et al. J. Pharmacol. Exp. Ther. 330 (2) :608-612 (2009)
Background Reference 04
Bochner, B.S. Clin. Exp. Allergy 39 (3) :317-324 (2009)
Other Product Names
Sialic acid-binding Ig-like lectin 8, Siglec-8, Sialoadhesin family member 2, SAF-2, SIGLEC8, SAF2
Tested Applications
WB, IHC-P
Protein ID
25009268
Physical Properties
Liquid

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