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CSTA Antibody

CAT: 0223-57-666Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-666Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
NCBI Gene ID
1475
Swiss Prot
P01040
Accession Number
P01040
Host
Rabbit
Reactivity
Human
Immunogen
This CSTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the C-terminal region of human CSTA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
11 kDa
Fragment
Rabbit Ig
Symbol
CSTA
NCBI Official Name
Cystatin-A
NCBI Organism
Homo sapiens
Background Reference 01
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19 (21) :4296-4303 (2010)
Background Reference 02
Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21 (7) :1223-1232 (2010)
Background Reference 03
Takai, T., et al. J. Immunol. 183 (12) :7958-7965 (2009)
Background Reference 04
Vasilopoulos, Y., et al. Eur. J. Hum. Genet. 16 (8) :1002-1009 (2008)
Other Product Names
Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA
Tested Applications
WB, IHC-P
Protein ID
118177
Physical Properties
Liquid

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