CSTA Antibody

• Background:

  The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.

• NCBI Gene ID:

  1475

• Swiss Prot:

  P01040

• Accession Number:

  P01040

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CSTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the C-terminal region of human CSTA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  11 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CSTA

• NCBI Official Name:

  Cystatin-A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19 (21) :4296-4303 (2010)

• Background Reference 02:

  Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21 (7) :1223-1232 (2010)

• Background Reference 03:

  Takai, T., et al. J. Immunol. 183 (12) :7958-7965 (2009)

• Background Reference 04:

  Vasilopoulos, Y., et al. Eur. J. Hum. Genet. 16 (8) :1002-1009 (2008)

• Other Product Names:

  Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA

• Tested Applications:

  WB, IHC-P

• Protein ID:

  118177

• Physical Properties:

  Liquid