TEAD2 Antibody

• Background :

  Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') . May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

• NCBI Gene ID :

  8463

• Swiss Prot :

  Q15562

• Accession Number :

  Q15562

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the Central region of human TEAD2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  49 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  TEAD2

• NCBI Official Name :

  Transcriptional enhancer factor TEF-4

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02 :

  Tian, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (16) :7293-7298 (2010)

• Background Reference 03 :

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 04 :

  Zhang, H., et al. J. Biol. Chem. 284 (20) :13355-13362 (2009)

• Other Product Names :

  Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2, TEAD2, TEF4

• Tested Applications :

  WB

• Protein ID :

  21264529

• Physical Properties :

  Liquid