GNAQ Antibody

• Background:

  This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

• NCBI Gene ID:

  2776

• Swiss Prot:

  P50148

• Accession Number:

  P50148

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GNAQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human GNAQ.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GNAQ

• NCBI Official Name:

  Guanine nucleotide-binding protein G (q) subunit alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dratviman-Storobinsky, O., et al. Invest. Ophthalmol. Vis. Sci. 51 (12) :6180-6182 (2010)

• Background Reference 02:

  Crouthamel, M., et al. Mol. Pharmacol. 78 (4) :767-777 (2010)

• Background Reference 03:

  Chillar, A., et al. Biochemistry 49 (30) :6365-6374 (2010)

• Background Reference 04:

  Klenke, S., et al. Pharmacogenet. Genomics 20 (8) :476-484 (2010)

• Other Product Names:

  Guanine nucleotide-binding protein G (q) subunit alpha, Guanine nucleotide-binding protein alpha-q, GNAQ, GAQ

• Tested Applications:

  WB

• Protein ID:

  251757492

• Physical Properties:

  Liquid