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GNAQ Antibody

CAT: 0223-57-538Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-538Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
NCBI Gene ID
2776
Swiss Prot
P50148
Accession Number
P50148
Host
Rabbit
Reactivity
Human
Immunogen
This GNAQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human GNAQ.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GNAQ
NCBI Official Name
Guanine nucleotide-binding protein G (q) subunit alpha
NCBI Organism
Homo sapiens
Background Reference 01
Dratviman-Storobinsky, O., et al. Invest. Ophthalmol. Vis. Sci. 51 (12) :6180-6182 (2010)
Background Reference 02
Crouthamel, M., et al. Mol. Pharmacol. 78 (4) :767-777 (2010)
Background Reference 03
Chillar, A., et al. Biochemistry 49 (30) :6365-6374 (2010)
Background Reference 04
Klenke, S., et al. Pharmacogenet. Genomics 20 (8) :476-484 (2010)
Other Product Names
Guanine nucleotide-binding protein G (q) subunit alpha, Guanine nucleotide-binding protein alpha-q, GNAQ, GAQ
Tested Applications
WB
Protein ID
251757492
Physical Properties
Liquid

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