TERT Antibody

• Background:

  Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

• NCBI Gene ID:

  7015

• Swiss Prot:

  O14746

• Accession Number:

  O14746

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TERT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1104-1132 amino acids from human TERT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  127 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TERT

• NCBI Official Name:

  Telomerase reverse transcriptase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sekaric, P., J. Virol. 82 (1), 71-76 (2008) Okawa, T., Genes Dev. 21 (21), 2788-2803 (2007)

• Other Product Names:

  Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2, TERT, EST2, TCS1, TRT

• Tested Applications:

  WB, IHC-P, IF, Flow

• Physical Properties:

  Liquid