TERT Antibody

CAT: 0223-57-483Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-483Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
NCBI Gene ID
7015
Swiss Prot
O14746
Accession Number
O14746
Host
Rabbit
Reactivity
Human
Immunogen
This TERT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1104-1132 amino acids from human TERT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Cell Cycle, Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
127 kDa
Fragment
Rabbit Ig
Symbol
TERT
NCBI Official Name
Telomerase reverse transcriptase
NCBI Organism
Homo sapiens
Background Reference 01
Sekaric, P., J. Virol. 82 (1), 71-76 (2008) Okawa, T., Genes Dev. 21 (21), 2788-2803 (2007)
Other Product Names
Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2, TERT, EST2, TCS1, TRT
Tested Applications
WB, IHC-P, IF, Flow
Physical Properties
Liquid

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